A new metabolite of butylated hydroxyanisole in man
Copyright policy )A new metabolite of butylated hydroxyanisole in man
AbstractButylated hydroxyanisole (I) is one of the most commonly used food antioxidants. Its use has been suggested to inhibit a variety of carcinogenic responses. The present study on the disposition kinetics of (I) in man indicates that contrary to previous reports, (I) undergoes significant O‐demethylation in the body yielding a tert‐butyl hydroquinone. It is suggested that this metabolic conversion may be responsible for some of the in vivo activities of (I) against chemical carcinogens.
- University of Illinois at Urbana–Champaign United States
- University of Illinois System United States
Male, Chromatography, Gas, Sulfates, Butylated Hydroxyanisole, Glucuronates, Anisoles, Gas Chromatography-Mass Spectrometry, Hydroquinones, Dealkylation, Humans, Biotransformation
Male, Chromatography, Gas, Sulfates, Butylated Hydroxyanisole, Glucuronates, Anisoles, Gas Chromatography-Mass Spectrometry, Hydroquinones, Dealkylation, Humans, Biotransformation
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