AbstractVenous malformations are the most common congenital vascular malformations, and the incidence rate is high. Previous studies have confirmed that a variety of polymorphisms within the miRNA functional region are associated with tumor susceptibility. We examined the correlation between miR‐618 rs2682818 C>A and risk of developing venous malformation in a southern Chinese population (1113 patients and 1158 controls). TaqMan genotyping of miR‐618 rs2682818 C>A was conducted utilizing real‐time fluorescent quantitative PCR. The miR‐618 rs2682818 polymorphism was not correlated with susceptibility to venous malformation (CA/AA vs. CC: adjusted odds ratio [AOR] = 1.00, 95% confidence interval [CI] = 0.81–1.25, p = 0.994; AA vs. CC/CA: AOR = 1.10, 95% CI = 0.73–1.65, p = 0.646). Stratified analysis of different subtypes of venous malformation revealed that there was no significant difference in the rs2682818 C>A polymorphism genotypes across these subtypes. Our results indicate that miR‐618 rs2682818 C>A polymorphism is not correlated with the susceptibility to venous malformation.