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Azathioprine in Rheumatoid Arthritis A Double‐Blind, Cross‐Over Study

Name: Azathioprine in Rheumatoid Arthritis A Double‐Blind, Cross‐Over Study
Keywords: Adult, Male, Analysis of Variance, Clinical Trials as Topic, Latex, Alopecia, Blood Sedimentation, Microspheres, Immunoglobulin A, Injections, Intra-Articular

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1973Publisher:WileyJournal:Arthritis & Rheumatism, volume 16, pages 411-418 (issn: 0004-3591, eissn: 1529-0131,

Authors: Murray B. Urowitz; Waldemar Pruzanski; Smythe Ha; M A Ogryzio; Duncan A. Gordon;

doi: 10.1002/art.1780160319

pmid: 4267682

Azathioprine in Rheumatoid Arthritis A Double‐Blind, Cross‐Over Study

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Abstract

AbstractSeventeen patients with classic rheumatoid arthritis resistant to conventional therapy were treated in a double‐blind, cross‐over study with azathioprine (2.0 to 2.5 mg/kg/day) and placebo for two 16‐week periods. Patients receiving azathioprine showed significant improvement in articular index, joint count, grip strength and effusions, manifest by 6 weeks but greater at 16 weeks. Erythrocyte sedimentation rate and latex titer did not change. White blood cell counts decreased on azathioprine, but normal counts did not preclude a response. Rash, nausea and hair thinning occurred in only 4 patients.

Related Organizations

University of Toronto
Canada

Keywords

Adult, Male, Analysis of Variance, Clinical Trials as Topic, Latex, Alopecia, Blood Sedimentation, Microspheres, Immunoglobulin A, Injections, Intra-Articular, Arthritis, Rheumatoid, Immunoglobulin M, Immunoglobulin G, Activities of Daily Living, Azathioprine, Humans, Female, Drug Eruptions, Lymphocytes, Aged

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	144
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%