Novel Nitrofurazone Derivatives Endowed with Antimicrobial Activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2008 English Publisher:WileyJournal:Archiv der Pharmazie, volume 341, pages 655-660 (issn: 0365-6233, eissn: 1521-4184,

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Authors: Dalci J, Brondani; Nelly, Caetano; Diogo R de M, Moreira; Rogério R, Soares; Vânia T, Lima; Janete M, de Araújo; Fabiane C, de Abreu; +3 Authors

doi: 10.1002/ardp.200700243

pmid: 18720338

Novel Nitrofurazone Derivatives Endowed with Antimicrobial Activity

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Abstract

AbstractThe N‐alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin‐resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.

Related Organizations

UNIVERSIDADE DE SAO PAULO
Brazil
Universidade Federal de Pernambuco
Brazil
Federal University of Alagoas
Brazil

Keywords

Structure-Activity Relationship, Antifungal Agents, Molecular Structure, Drug Design, Nitrofurazone, Microbial Sensitivity Tests, Anti-Bacterial Agents

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