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New L‐Dopa Codrugs as Potential Antiparkinson Agents

descriptionPublicationkeyboard_double_arrow_right Article 25 Jun 2008 Italy English Publisher:WileyJournal:Archiv der Pharmazie, volume 341, pages 412-417 (issn: 0365-6233, eissn: 1521-4184,

Authors: SOZIO, Piera; IANNITELLI, ANTONIO; CERASA LS; CACCIATORE, Ivana; CORNACCHIA, CATIA; GIORGIONI G; RICCIUTELLI M; +3 Authors

doi: 10.1002/ardp.200700228

pmid: 18581391

handle: 11564/134287 , 11581/114392

New L‐Dopa Codrugs as Potential Antiparkinson Agents

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Abstract

AbstractThis paper reports the synthesis and preliminary evaluation of newL‐dopa (LD) conjugates (1and2) obtained by joining LD with two different natural antioxidants, caffeic acid and carnosine, respectively. The antioxidant efficacy of compounds1and2was assessed by evaluating plasmatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the rat. Rat striatal concentration of LD and dopamine (DA), and central nervous effects were evaluated after oral administration of the codrugs1and2. The results suggest that, though our codrugs are devoid of significant antioxidant activity, they are able to induce sustained delivery of DA in rat striatum and can improve LD and DA release in the brain.

Country

Italy

Related Organizations

University of Camerino
Italy
University of Chieti-Pescara
Italy

Keywords

Glutathione Peroxidase, Superoxide Dismutase, Carnosine, Dopamine, Administration, Oral, Parkinson Disease, Antioxidants, Corpus Striatum, Rats, Antiparkinson Agents, Levodopa, Caffeic Acids, Animals

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	29
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%