Synthesis of Four Natural Prenylflavonoids and Their Estrogen‐like Activities

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2007 English Publisher:WileyJournal:Archiv der Pharmazie, volume 340, pages 372-376 (issn: 0365-6233, eissn: 1521-4184,

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Authors: Xiaowu, Dong; Yongjian, Fan; Lingjun, Yu; Yongzhou, Hu;

doi: 10.1002/ardp.200700057

pmid: 17610303

Synthesis of Four Natural Prenylflavonoids and Their Estrogen‐like Activities

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Abstract

AbstractFour prenylflavonoids, bavachin 1, isobavachin 2, 7,4′‐dihydroxy‐8‐prenylflavone 3, and 8‐prenylapigenin 4 were synthesized and recognized for possessing estrogen‐like activity in MCF‐7/BOS cells, as evaluated by an estrogen‐screening assay. All compounds significantly stimulated the proliferation of MCF‐7/BOS cells in a dose‐dependent manner. Isobavachin 2 showed the most potent activity, while bavachin 1 was the weakest. The estrogenic potency of these compounds is ranked as follows: 2 > 4 > 3 > 1.

Related Organizations

Zhejiang Ocean University
China (People's Republic of)

Keywords

Flavonoids, Cell Line, Tumor, Humans, Phytoestrogens

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