The Oriented Development of Antituberculotics: Salicylanilides
Copyright policy )The Oriented Development of Antituberculotics: Salicylanilides
AbstractOn the basis of our previous results 22 salicylanilides were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. The Free‐Wilson method was used to evaluate structure‐antimycobacterial activity relationships. 4‐Chloro‐N‐(4‐propylphenyl)salicylamide and 5‐chloro‐N‐(4‐propylphenyl)salicylamide were selected for preclinical studies.
- Hans Knöll Institute Germany
- Charles University Czech Republic
- Slovak University of Technology in Bratislava Slovakia
- Leibniz Association Germany
Structure-Activity Relationship, Mycobacterium kansasii, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Salicylanilides, Mycobacterium avium
Structure-Activity Relationship, Mycobacterium kansasii, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Salicylanilides, Mycobacterium avium
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