Synthesis and Antiviral Evaluation of Novel Cyclopropyl Nucleosides, Phosphonate Nucleosides and Phosphonic Acid Nucleosides
Copyright policy )Synthesis and Antiviral Evaluation of Novel Cyclopropyl Nucleosides, Phosphonate Nucleosides and Phosphonic Acid Nucleosides
AbstractNovel phenyl‐branched cyclopropyl nucleosides, phosphonates, and phosphonic acid analogues were designed and synthesized as potential antiviral agents. Coupling of the mesylate 10 with natural bases (U, T, C, A) and desilylation/hydrolysis afforded a series of novel cyclopropyl nucleosides 15–18. Phosphonate and phosphonic acid nucleosides 22–29 were also readily synthesized from the mesylate 21. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV‐1, HSV‐1, HSV‐2, and HCMV.
- Korean Association Of Science and Technology Studies Korea (Republic of)
- Chosun University Korea (Republic of)
- Korea Institute of Science and Technology Korea (Republic of)
Cyclopropanes, Molecular Structure, Organophosphonates, Cytomegalovirus, Humans, Nucleosides, Microbial Sensitivity Tests, Antiviral Agents, Cell Line
Cyclopropanes, Molecular Structure, Organophosphonates, Cytomegalovirus, Humans, Nucleosides, Microbial Sensitivity Tests, Antiviral Agents, Cell Line
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