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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archiv der Pharmaziearrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Archiv der Pharmazie
Article . 1993 . Peer-reviewed
License: Wiley Online Library User Agreement
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Archiv der Pharmazie
Article . 1993
Data sources: Europe PubMed Central
https://dx.doi.org/10.1002/ard...
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Phenytoin‐Lipid Conjugates as Potential Prodrugs of Phenytoin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1993 English Publisher:WileyJournal:Archiv der Pharmazie, volume 326, pages 477-481 (issn: 0365-6233, eissn: 1521-4184, Copyright policy )
Authors: G K, Scriba;

doi: 10.1002/ardp.19933260810

pmid: 8215846

Phenytoin‐Lipid Conjugates as Potential Prodrugs of Phenytoin

Abstract

AbstractPhenytoin‐1‐triglycerides and phenytoin‐2‐triglycerides were synthesized as potential prodrugs of phenytoin by covalent binding of 3‐hydroxymethylphenytoin by succinic acid to the positions 1 and 2 of diglycerides, respectively. The corresponding 1‐ and 2‐monoglycerides were prepared. In addition, replacement of glycerol by 3‐hydroxy‐2‐hydroxymethylpropionic acid furnished lipids that allowed direct coupling of 3‐hydroxyme‐thylphenytoin. The lipid conjugates proved to be substrates for pancreatic lipase in vitro.

Related Organizations
Keywords

Swine, Phenytoin, Animals, Prodrugs, Lipase, Lipids, Pancreas, Triglycerides

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Average
Top 10%
Top 10%
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