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Enantioselective Addition of Pyrazoles to Dienes**

descriptionPublicationkeyboard_double_arrow_right Article 28 Apr 2021 United States Publisher:WileyJournal:Angewandte Chemie International Edition, volume 60, pages 19,660-19,664 (issn: 1433-7851, eissn: 1521-3773,

Authors: Alexander Y. Jiu; Hannah S. Slocumb; Charles S. Yeung; Xiao‐Hui Yang; Vy M. Dong;

doi: 10.1002/anie.202105679 , 10.26434/chemrxiv.14489379.v1 , 10.1002/ange.202105679

pmid: 34145705

pmc: PMC8889753

Enantioselective Addition of Pyrazoles to Dienes**

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Abstract

AbstractWe report the first enantioselective addition of pyrazoles to 1,3‐dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd0‐catalyzed ligand‐to‐ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.

Country

United States

Related Organizations

University of California, Irvine
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University of California System
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Beijing Institute of Technology
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Beijing Institute of Technology (BIT)
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Keywords

Molecular Structure, 1, Organic Chemistry, Stereoisomerism, Ligands, Catalysis, hydroamination, pyrazole, Alkadienes, Pd-catalysis, enantioselectivity, Chemical Sciences, 3-diene, Pyrazoles, Palladium

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