Pseudo Natural Products—Chemical Evolution of Natural Product Structure
Copyright policy )Pseudo Natural Products—Chemical Evolution of Natural Product Structure
AbstractPseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments. They inherit key biological characteristics of the guiding natural product, such as chemical and physiological properties, yet define small molecule chemotypes with unprecedented or unexpected bioactivity. We iterate the design principles underpinning PNP scaffolds and highlight their syntheses and biological investigations. We provide a cheminformatic analysis of PNP collections assessing their molecular properties and shape diversity. We propose and discuss how the iterative analysis of NP structure, design, synthesis, and biological evaluation of PNPs can be regarded as a human‐driven branch of the evolution of natural products, that is, a chemical evolution of natural product structure.
- Max Planck Society Germany
- TU Dortmund University Germany
- Max Planck Institute of Molecular Physiology Germany
- University of Canterbury New Zealand
- White Rose Consortium: University of Leeds; University of Sheffield; University of York United Kingdom
Natural products, Biological Products, Molecular Structure, natural products, Biological activity, Natural selection, biological activity, chemical biology, natural selection, Minireviews, Chemical biology, Fragment-based design, Humans, fragment-based design
Natural products, Biological Products, Molecular Structure, natural products, Biological activity, Natural selection, biological activity, chemical biology, natural selection, Minireviews, Chemical biology, Fragment-based design, Humans, fragment-based design
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