Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery
Copyright policy )Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery
AbstractA large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core–shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug‐loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug‐core silica–shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug‐loading nanoparticles.
- University of Adelaide Australia
- University of Queensland Australia
- University of Queensland Australia
- Griffith University Australia
- University of Queensland Australia
Silicon, Curcumin, Surface Properties, Antineoplastic Agents, Biomaterials, Mice, Drug Delivery Systems, Cell Line, Tumor, biomimetic synthesis, cancer, Animals, Humans, Particle Size, Cell Proliferation, 0306 Physical Chemistry (incl. Structural), Ovarian Neoplasms, Macromolecular and materials chemistry, Drug Carriers, Nanobiotechnology, General Medicine, 1600 Chemistry, Chemical sciences, drug delivery, peptides, Nanoparticles, nanoparticles, Female, Drug Screening Assays, Antitumor, 03 Chemical Sciences, Peptides, Hydrophobic and Hydrophilic Interactions
Silicon, Curcumin, Surface Properties, Antineoplastic Agents, Biomaterials, Mice, Drug Delivery Systems, Cell Line, Tumor, biomimetic synthesis, cancer, Animals, Humans, Particle Size, Cell Proliferation, 0306 Physical Chemistry (incl. Structural), Ovarian Neoplasms, Macromolecular and materials chemistry, Drug Carriers, Nanobiotechnology, General Medicine, 1600 Chemistry, Chemical sciences, drug delivery, peptides, Nanoparticles, nanoparticles, Female, Drug Screening Assays, Antitumor, 03 Chemical Sciences, Peptides, Hydrophobic and Hydrophilic Interactions
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