Cross‐Regulation of an Artificial Metalloenzyme
Copyright policy )Cross‐Regulation of an Artificial Metalloenzyme
AbstractCross‐regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross‐regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.
- University of Basel Switzerland
urease, Enrofloxacin, biocatalysis, General Medicine, Hydrogen-Ion Concentration, Urease, Communications, Canavalia, Hydrogenase, artificial metalloenzymes, Ammonia, Biomimetics, Metalloproteins, Biocatalysis, Urea, cross-regulation, hydrogenation
urease, Enrofloxacin, biocatalysis, General Medicine, Hydrogen-Ion Concentration, Urease, Communications, Canavalia, Hydrogenase, artificial metalloenzymes, Ammonia, Biomimetics, Metalloproteins, Biocatalysis, Urea, cross-regulation, hydrogenation
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