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Thiamine Biosynthesis in Escherichia coli: Identification of the Intermediate and By‐Product Derived from Tyrosine

descriptionPublicationkeyboard_double_arrow_right Article 05 Dec 2007 United Kingdom Publisher:WileyJournal:Angewandte Chemie International Edition, volume 46, pages 9,223-9,226 (issn: 1433-7851, eissn: 1521-3773,

Authors: Kriek, Marco; Martins, Filipa; Challand, Martin R.; Croft, Anna K.; Roach, Peter L.;

doi: 10.1002/anie.200702554 , 10.1002/ange.200702554

pmid: 17969213

Thiamine Biosynthesis in Escherichia coli: Identification of the Intermediate and By‐Product Derived from Tyrosine

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Abstract

In anaerobic organisms such as E. coli the tyrosine lyase ThiH is essential for the biosynthesis of the thiazole moiety of the vitamin thiamine. ThiH is a member of the radical AdoMet family. The products formed by cleavage of tyrosine in vitro have been identified and suggest a radical-mediated cleavage resulting in p-cresol and dehydroglycine which is hydrolyzed to glyoxylate.

Country

United Kingdom

Related Organizations

University of Southampton
United Kingdom
University of Wales
United Kingdom
Bangor University
United Kingdom

Keywords

570, Cresols, Escherichia coli Proteins, Mutation, Escherichia coli, Glycine, Glyoxylates, Tyrosine, Thiamine

1 Research products, page 1 of 1

2-iminoacetate synthase
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