Optogenetic Control of Voltage‐Gated Calcium Channels
Copyright policy )Optogenetic Control of Voltage‐Gated Calcium Channels
AbstractVoltage‐gated Ca2+ (CaV) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo‐tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV‐mediated physiological processes.
- Beijing Normal University China (People's Republic of)
- Beijing Normal University China (People's Republic of)
- Neijiang Normal University China (People's Republic of)
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Beijing Normal University (Chine) China (People's Republic of)
calcium signaling, Protein Engineering, Biochemistry, Cell Line, Mice, Animals, Humans, Myocytes, Cardiac, Calcium Signaling, Amino Acids, optogenetics, Molecular Biology, Monomeric GTP-Binding Proteins, and Proteins, ion channels, protein engineering, Communications, Cellular and Molecular Physiology, Optogenetics, Chemistry, HEK293 Cells, Calcium, synthetic biology, Calcium Channels, Peptides
calcium signaling, Protein Engineering, Biochemistry, Cell Line, Mice, Animals, Humans, Myocytes, Cardiac, Calcium Signaling, Amino Acids, optogenetics, Molecular Biology, Monomeric GTP-Binding Proteins, and Proteins, ion channels, protein engineering, Communications, Cellular and Molecular Physiology, Optogenetics, Chemistry, HEK293 Cells, Calcium, synthetic biology, Calcium Channels, Peptides
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