Determination of Enantiomeric Excess in Amine Derivatives with Molecular Self‐Assemblies
Copyright policy )Determination of Enantiomeric Excess in Amine Derivatives with Molecular Self‐Assemblies
AbstractWe report the first fluorescence‐based assay for the rapid determination of the ee value of amines, amino alcohols, and amino acid esters. The method uses the self‐assembly of 2‐formylphenylboronic acid with a chiral diol and a chiral amine or derivatives (of unknown chirality) to produce two diastereomeric iminoboronates that differ in their fluorescence intensity and polarization. The approach allows for the accurate determination of the ee value of chiral amines with errors of just 1–2 %. We believe that this application of orthogonal dynamic covalent self‐assembly in the determination of the enantioselectivity will lead to the development of high‐throughput procedures for the determination of chirality.
- University System of Ohio United States
- Bowling Green State University United States
- University of Bath United Kingdom
Kinetics, Support Vector Machine, Benzaldehydes, Molecular Conformation, Stereoisomerism, Amines, Amino Acids, Amino Alcohols, Boronic Acids, Fluorescent Dyes
Kinetics, Support Vector Machine, Benzaldehydes, Molecular Conformation, Stereoisomerism, Amines, Amino Acids, Amino Alcohols, Boronic Acids, Fluorescent Dyes
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