Microstructural white matter changes in carriers of the DYT1 gene mutation
Copyright policy )Microstructural white matter changes in carriers of the DYT1 gene mutation
AbstractWe tested the hypothesis that the DYT1 genotype is associated with a disorder of anatomical connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic resonance imaging (DTI) to assess the microstructure of white matter pathways in mutation carriers and control subjects. Fractional anisotropy (FA), a measure of axonal integrity and coherence, was reduced (p < 0.005) in the subgyral white matter of the sensorimotor cortex of DYT1 carriers. Abnormal anatomical connectivity of the supplementary motor area may contribute to the susceptibility of DYT1 carriers to develop clinical manifestations of dystonia. Ann Neurol 2004
- Beth Israel Deaconess Medical Center United States
- Northwell Health United States
- Center for Neurosciences United States
- North Shore University Hospital United States
- New York University United States
Adult, Cerebral Cortex, Male, Middle Aged, Dystonia, Diffusion Magnetic Resonance Imaging, Case-Control Studies, Mutation, Humans, Female, Genetic Predisposition to Disease, Molecular Chaperones
Adult, Cerebral Cortex, Male, Middle Aged, Dystonia, Diffusion Magnetic Resonance Imaging, Case-Control Studies, Mutation, Humans, Female, Genetic Predisposition to Disease, Molecular Chaperones
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