Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD
Copyright policy )Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD
AbstractPrevious studies have found heterogeneous association between DAT1‐3′‐UTR‐VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD − CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD − CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identify variants that have different transmission patterns in the two phenotypic subgroups. After multiple‐test correction, rs40184 and rs2652511 were significant in TDT tests. Further heterogeneity test found the two SNPs had a significant transmission pattern difference between ADHD + CD and ADHD − CD children, indicating that DAT1 has a significantly greater genetic influence on ADHD without CD. Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD. © 2007 Wiley‐Liss, Inc.
- Radboud University Nijmegen Netherlands
- Massachusetts General Hospital United States
- University of Göttingen Germany
- Trinity College Dublin Ireland
- St. James's Hospital Ireland
Conduct Disorder, Genetic Markers, Male, 2716 Genetics (clinical), DCN 1: Perception and Action, Genotype, DCN 2: Functional Neurogenomics, NCEBP 9: Mental health, Medizin, 2804 Cellular and Molecular Neuroscience, 610, 610 Medicine & health, Comorbidity, NCMLS 6: Genetics and epigenetic pathways of disease, Polymorphism, Single Nucleotide, Linkage Disequilibrium, UMCN 5.1: Genetic defects of metabolism, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, 2738 Psychiatry and Mental Health, Cellular and Molecular Neuroscience, Genetic Heterogeneity, IGMD 3: Genomic disorders and inherited multi-system disorders, SDG 3 - Good Health and Well-being, Gene Frequency, 616, 10058 Child and Adolescent Psychiatry, DCN 3: Neuroinformatics, Humans, Genetics(clinical), Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Child, Alleles, UMCN 3.2: Cognitive neurosciences, ddc:610, Dopamine Plasma Membrane Transport Proteins, Chi-Square Distribution, Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Incidence, Europe, Psychiatry and Mental health, Haplotypes, Attention Deficit Disorder with Hyperactivity, Female, ddc: ddc:610
Conduct Disorder, Genetic Markers, Male, 2716 Genetics (clinical), DCN 1: Perception and Action, Genotype, DCN 2: Functional Neurogenomics, NCEBP 9: Mental health, Medizin, 2804 Cellular and Molecular Neuroscience, 610, 610 Medicine & health, Comorbidity, NCMLS 6: Genetics and epigenetic pathways of disease, Polymorphism, Single Nucleotide, Linkage Disequilibrium, UMCN 5.1: Genetic defects of metabolism, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, 2738 Psychiatry and Mental Health, Cellular and Molecular Neuroscience, Genetic Heterogeneity, IGMD 3: Genomic disorders and inherited multi-system disorders, SDG 3 - Good Health and Well-being, Gene Frequency, 616, 10058 Child and Adolescent Psychiatry, DCN 3: Neuroinformatics, Humans, Genetics(clinical), Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Child, Alleles, UMCN 3.2: Cognitive neurosciences, ddc:610, Dopamine Plasma Membrane Transport Proteins, Chi-Square Distribution, Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Incidence, Europe, Psychiatry and Mental health, Haplotypes, Attention Deficit Disorder with Hyperactivity, Female, ddc: ddc:610
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