Non‐immune hydrops fetalis: A short review of etiology and pathophysiology

descriptionPublicationkeyboard_double_arrow_right Article 02 Feb 2012 English Publisher:WileyJournal:American Journal of Medical Genetics Part A, volume 158A, pages 597-605 (issn: 1552-4825, eissn: 1552-4833,

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Authors: Carlo, Bellini; Raoul C M, Hennekam;

doi: 10.1002/ajmg.a.34438

pmid: 22302731

Non‐immune hydrops fetalis: A short review of etiology and pathophysiology

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Abstract

AbstractHydrops fetalis is an excessive accumulation of fetal fluid. Hydrops is traditionally classified into either immune or non‐immune hydrops (NIHF), but in practice, nowadays in the Western world >90% of hydrops is of non‐immune origin. The basis of the disorder is an imbalance in the regulation of fetal fluid movement between the vascular and interstitial space. We previously suggested a diagnostic flow‐chart for NIHF. In this short review we describe the main mechanisms leading to NIHF. © 2012 Wiley Periodicals, Inc.

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Keywords

Lymphatic System, Fetus, Hydrops Fetalis, Humans, Body Fluids

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