
doi: 10.1002/ajmg.10258
pmid: 11932986
AbstractTeratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain. © 2002 Wiley‐Liss, Inc.
Pregnancy in Diabetics, Abnormalities, Drug-Induced, Cholesterol, Teratogens, Maternal Exposure, Pregnancy, Holoprosencephaly, Mutation, Trans-Activators, Animals, Humans, Female, Hedgehog Proteins, Signal Transduction
Pregnancy in Diabetics, Abnormalities, Drug-Induced, Cholesterol, Teratogens, Maternal Exposure, Pregnancy, Holoprosencephaly, Mutation, Trans-Activators, Animals, Humans, Female, Hedgehog Proteins, Signal Transduction
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