Volume fluctuations in residual limbs can significantly affect the fit of prosthetic sockets, causing discomfort and instability when wearing a limb prosthesis. As a result, users must frequently visit prosthetic centers for socket adjustments or replacements, which is time‐consuming and limiting. This study introduces a new transfemoral socket that incorporates a motorized cable‐driven mechanism and a sensorized liner, allowing it to adapt to changes in residual limb volume based on interface pressures. Users can control the socket in both open‐ and closed‐loop modes using a customized mobile application. The socket is able to withstand compressive mechanical loads of up to 900 N and demonstrates effective biomechanical coupling capabilities. A mathematical model guide the design of the system and is experimentally verified. To validate the system, an in vitro residual limb simulator with a hydraulic chamber is utilized, enabling volume adjustments of ±7.5%. In closed‐loop mode, the smart socket effectively adjusts its volume to maintain interface pressure within the target range of 70–80 kPa. This innovative smart socket has the potential to enhance user satisfaction by allowing individuals with lower limb amputations to self‐adjust their sockets as needed, ensuring a proper fit and safe interface pressures on tissues.