ABSTRACTBackgroundTargeting Cu transport proteins is an innovative therapeutic approach for combating cancer. However, the mechanisms underlying the malignant potential of Cu transport proteins remain largely unknown. To address this issue, we focused on the oncogenic potential of copper chaperones for superoxide dismutase (CCS) in colorectal cancer (CRC).MethodsWe investigated the association between the prognosis and the copper transport protein, CCS, using clinical samples. The function of CCS was analyzed to assess the proliferation and migration potential of CRC cells.ResultsUnivariate and multivariate analyses revealed that CCS was an independent prognostic factor for disease‐free survival and overall survival. CCS is closely related to the malignant potential of CRC, which includes proliferation, migration, and the MEK–ERK pathway.ConclusionsThus, CCS is a valuable biomarker and therapeutic target for CRC.