AbstractMXenes, a novel member of the 2D material family, shows promising potential in stabilizing isolated atoms and maximizing the atom utilization efficiency for catalytic applications. This review focuses on the role of MXenes as support for single‐atom catalysts (SACs) for various electrochemical reactions, namely the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), carbon dioxide reduction reaction (CO2RR), and nitrogen reduction reaction (NRR). First, state‐of‐the‐art characterization and synthesis methods of MXenes and MXene‐supported SACs are discussed, highlighting how the unique structure and tunable functional groups enhance the catalytic performance of pristine MXenes and contribute to stabilizing SAs. Then, recent studies of MXene‐supported SACs in different electrocatalytic areas are examined, including experimental and theoretical studies. Finally, this review discusses the challenges and outlook of the utilization of MXene‐supported SACs in the field of electrocatalysis.