In article number 1900913, Tony Jun Huang and co‐workers utilize an acoustic‐vortex‐based active mixing strategy to demonstrate an acoustic‐based platform capable of synthesizing particulate nanomaterials in a controllable and reproducible manner. This platform allows dynamic and independent dictation of the mixing process simply by adjusting the strength of the acoustic vortex. Using the platform, the synthesis of nanomaterials is demonstrated such as polymeric nanoparticles, chitosan nanoparticles, organic–inorganic hybrid nanomaterials, metal–organic frameworks biocomposites, and lipid–DNA complexes. [Image: see text]