Radial extracorporeal shock wave therapy (rESWT) has been widely used to treat orthopedic disorders and has shown promising clinical results. However, treatments largely rely on clinicians' personal experiences and arbitrary judgments. In article number 1700797, Xiaodong Chen and co‐workers develop a combined experimental and numerical methodology to quantify and characterize pressure fields generated by a rESWT device inside biotissues. [Image: see text]