Abstract2D monolayers supporting a wide variety of highly confined plasmons, phonon polaritons, and exciton polaritons can be vertically stacked in van der Waals heterostructures (vdWHs) with controlled constituent layers, stacking sequence, and even twist angles. vdWHs combine advantages of 2D material polaritons, rich optical structure design, and atomic scale integration, which have greatly extended the performance and functions of polaritons, such as wide frequency range, long lifetime, ultrafast all‐optical modulation, and photonic crystals for nanoscale light. Here, the state of the art of 2D material polaritons in vdWHs from the perspective of design principles and potential applications is reviewed. Some fundamental properties of polaritons in vdWHs are initially discussed, followed by recent discoveries of plasmons, phonon polaritons, exciton polaritons, and their hybrid modes in vdWHs. The review concludes with a perspective discussion on potential applications of these polaritons such as nanophotonic integrated circuits, which will benefit from the intersection between nanophotonics and materials science.