Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2
Copyright policy )Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2
AbstractOsteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one‐shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.
- Wuhan University China (People's Republic of)
- THE UNIVERSITY OF QUEENSLAND Australia
- The University of Queensland Australia
- Terrestrial Ecosystem Research Network Australia
- University of Queensland Australia
Temporomandibular-Joint, 2210 Mechanical Engineering, Intracellular Space, Molecular-Weight, Cell Line, Viscosupplementation, 2211 Mechanics of Materials, Osteoarthritis, Acid, Animals, Humans, Hyaluronic Acid, 2500 Materials Science, Arthritis, Silicon Dioxide, Manner, Synoviocytes, Rats, Molecular Weight, Nanomedicine, Sodium Hyaluronate, Nanoparticles, Joints, Hyaluronan Synthases, Porosity, Dna Delivery
Temporomandibular-Joint, 2210 Mechanical Engineering, Intracellular Space, Molecular-Weight, Cell Line, Viscosupplementation, 2211 Mechanics of Materials, Osteoarthritis, Acid, Animals, Humans, Hyaluronic Acid, 2500 Materials Science, Arthritis, Silicon Dioxide, Manner, Synoviocytes, Rats, Molecular Weight, Nanomedicine, Sodium Hyaluronate, Nanoparticles, Joints, Hyaluronan Synthases, Porosity, Dna Delivery
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