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Controlling Epileptiform Activity with Organic Electronic Ion Pumps

Authors: Williamson, Adam; Rivnay, Jonathan; Kergoat, Loig; Jonsson, Amanda; Inal, Sahika; Uguz, Ilke; Ferro, Marc; +6 Authors

Controlling Epileptiform Activity with Organic Electronic Ion Pumps

Abstract

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Country
Sweden
Keywords

Neurologi, Electrical Equipment and Supplies, Action Potentials, Electrons, Neuroengineering, Tissue Culture Techniques, PSS [PEDOT], Mice, PEDOT:PSS, Animals, Magnesium, CA1 Region, Hippocampal, gamma-Aminobutyric Acid, Ions, Epilepsy, Pyramidal Cells, Organic Electronic Ion Pump, Equipment Design, CA3 Region, Hippocampal, Organic Bioelectronics, Neurology, Chlorates, Anticonvulsants

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    149
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
149
Top 1%
Top 10%
Top 1%
Green
bronze