AbstractIn spite of advances in electronics and internet technologies, current healthcare remains hospital‐centred. Disruptive technologies are required to translate state‐of‐art wearable devices into next‐generation patient‐centered diagnosis and therapy. In this review, recent advances in the emerging field of soft wearable materials and devices are summarized. A prerequisite for such future healthcare devices is the need of novel materials to be mechanically compliant, electrically conductive, and biologically compatible. It is begun with an overview of the two viable design strategies reported in the literatures, which is followed by description of state‐of‐the‐art wearable healthcare devices for monitoring physical, electrophysiological, chemical, and biological signals. Self‐powered wearable bioenergy devices are also covered and sensing systems, as well as feedback‐controlled wearable closed‐loop biodiagnostic and therapy systems. Finally, it is concluded with an overall summary and future perspective.