Transparent and Gas‐Permeable Liquid Marbles for Culturing and Drug Sensitivity Test of Tumor Spheroids

descriptionPublicationkeyboard_double_arrow_right Article 20 Apr 2017 English Publisher:WileyJournal:Advanced Healthcare Materials, volume 6 (issn: 2192-2640, eissn: 2192-2659,

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Authors: Hualin, Li; Peng, Liu; Guneet, Kaur; Xi, Yao; Mengsu, Yang;

doi: 10.1002/adhm.201700185

pmid: 28426154

Transparent and Gas‐Permeable Liquid Marbles for Culturing and Drug Sensitivity Test of Tumor Spheroids

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Abstract

Transparent nanoparticle‐based liquid marbles with high gas‐permeability are prepared to culture tumor spheroids in 3D without the need of supplementary growth factor. The culturing process of spheroids from a population of cancer cells or a single cell in the transparent liquid marbles can be optically recorded continuously. Compared to monolayer cells and spheroids generated in multiwell plate, tumor spheroids cultured in the liquid marbles show enhanced viability under the treatment of chemotherapeutic drugs and small interfering RNA.

Related Organizations

City University of Hong Kong, Shenzhen Research Institute
China (People's Republic of)
City University of Hong Kong
China (People's Republic of)

Keywords

Drug Carriers, Antineoplastic Agents, MicroRNAs, Cell Line, Tumor, Neoplasms, Spheroids, Cellular, Humans, Nanoparticles, Drug Screening Assays, Antitumor

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