Programmed Cell Death

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 15 Sep 2006 English Publisher:Wiley-VCH Verlag GmbH & Co. KGaA

Authors: David L. Vaux; Andreas Strasser;

doi: 10.1002/3527600906.mcb.200400090

Programmed Cell Death

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Abstract

Apoptosis is a physiological process of cell suicide that is implemented by activation of latent proteases that demolish vital cellular constituents. Apoptosis is used to sculpt the body during development, to maintain constant cell number by balancing cell production by mitosis, and to remove cells that are damaged or infected. Failure of cells to undergo apoptosis can lead to cancer and autoimmune disease, and inappropriate apoptosis may contribute to or cause organ damage in degenerative disease and ischemic vascular injury. Keywords: Apoptosis; Bcl-2; Caspase; Death Receptor; IAP; p53; Programmed Cell Death

Related Organizations

Walter and Eliza Hall Institute of Medical Research
Australia

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