Toosendanin facilitates [3H]noradrenaline release from rat hippocampal slices
Copyright policy )Toosendanin facilitates [3H]noradrenaline release from rat hippocampal slices
AbstractSlices of hippocampus of the rat, preincubated with [3H]noradrenaline ([3H]NA), were used to investigate the effects of toosendanin on the release of [3H]NA. Toosendanin potently enhanced spontaneous 3H outflow. Seventy‐four percent of the enhancement was inhibited by reserpine pretreatment. The toosendanin‐induced 3H overflow was in a concentration‐dependent manner (5–60 μM) both in the presence and absence of extracellular calcium. Under Ca2+‐free conditions, the effect of toosendanin on 3H outflow was unchanged by TTX, but inhibited by Ca2+‐chelator BAPTA‐AM; dantrolene sodium failed to affect the toosendanin‐induced 3H outflow, while 3,4‐diaminopyridine showed an additive effect on the outflow with this substance. The findings suggest that in the absence of extracellular Ca2+, toosendanin enhances [3H]NA release through the liberation of intracellular Ca2+ stores.
- Chinese Academy of Sciences China (People's Republic of)
Potassium Channels, Reserpine, Dose-Response Relationship, Drug, Muscle Relaxants, Central, In Vitro Techniques, Hippocampus, Dantrolene, Rats, Rats, Sprague-Dawley, Norepinephrine, Isotope Labeling, Sympatholytics, Animals, Calcium, 4-Aminopyridine, Amifampridine, Neuromuscular Blocking Agents, Egtazic Acid, Chelating Agents, Drugs, Chinese Herbal
Potassium Channels, Reserpine, Dose-Response Relationship, Drug, Muscle Relaxants, Central, In Vitro Techniques, Hippocampus, Dantrolene, Rats, Rats, Sprague-Dawley, Norepinephrine, Isotope Labeling, Sympatholytics, Animals, Calcium, 4-Aminopyridine, Amifampridine, Neuromuscular Blocking Agents, Egtazic Acid, Chelating Agents, Drugs, Chinese Herbal
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