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FEBS Letters
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FEBS Letters
Article . 2018 . Peer-reviewed
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FEBS Letters
Article . 2019
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All I's on the RADAR: role of ADAR in gene regulation

Authors: Shevchenko, G; Morris, KV;

All I's on the RADAR: role of ADAR in gene regulation

Abstract

Adenosine to inosine (A‐to‐I) editing is the most abundant form of RNA modification in mammalian cells, which is catalyzed by adenosine deaminase acting on the double‐stranded RNA (ADAR) protein family. A‐to‐I editing is currently known to be involved in the regulation of the immune system, RNA splicing, protein recoding, microRNA biogenesis, and formation of heterochromatin. Editing occurs within regions of double‐stranded RNA, particularly within inverted Alu repeats, and is associated with many diseases including cancer, neurological disorders, and metabolic syndromes. However, the significance of RNA editing in a large portion of the transcriptome remains unknown. Here, we review the current knowledge about the prevalence and function of A‐to‐I editing by the ADAR protein family, focusing on its role in the regulation of gene expression. Furthermore, RNA editing‐independent regulation of cellular processes by ADAR and the putative role(s) of this process in gene regulation will be discussed.

Country
Australia
Related Organizations
Keywords

RNA editing, Adenosine, Adenosine Deaminase, RNA Splicing, non-coding RNA, Evolutionary biology, ADAR, Inosine, MicroRNAs, Gene Expression Regulation, Alu Elements, Biochemistry and cell biology, Heterochromatin, Medicinal and biomolecular chemistry, Animals, Humans, RNA Editing, adenosine to inosine, RNA, Double-Stranded

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    37
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
37
Top 10%
Average
Top 10%
Green
bronze