In order to give users reliable information/warning of changing space weather conditions that may affect a diverse range of technological systems, thoroughgoing knowledge of disturbed ionosphere behavior and its solar activity, local time, seasonal, latitudinal/longitudinal dependence, as well as possible hemispherical asymmetries are needed. Here investigations of differences in ionospheric effects are based on data obtained at different magnetic latitudes and longitudes of both hemispheres. Variability of main ionospheric parameters (foF2 and hmF2), obtained for Euro‐African and American sectors for geomagnetic storms of different intensity, which occurred within solar cycles 23 and 24, is analyzed. Ionospheric response to weak geomagnetic storms during the declining phase of the 23rd solar cycle and deep 23/24 solar minimum is found to be comparable with or even slightly stronger than that of strong storms under higher solar activity conditions, which might be partly related to specific impact of different drivers of geomagnetic activity. Hemispheric asymmetry of ionospheric response at middle latitudes, on average, is not a dominant and/or strong feature. The asymmetry in individual events may be well pronounced both in foF2 and hmF2, but mostly it seems to be an impact of other factors like seasonal variation, magnetic coordinates, or local time.