In contrast to the many uncertainties relating to angina pectoris is the circumstance that in a large proportion of cases the attack is only an incident in the history of arteriosclerosis. Since Edward Jenner demonstrated postmortem disease of the coronary arteries, the association of a lesion of these vessels with the disease has been accepted as one of the best attested facts in cardiac pathology. Not that it has helped much to explain the mysterious nature of the pain of the attack, or all of the phenomena of the paroxysm. Pain in arteriosclerosis, as we see it in other parts, deserves a more careful study than it has jret received. In the head there is the association of migraine with arterial disease, the severe and characteristic headaches of arteriosclerosis and high pressure, and the agonizing pain in some cases of embolism of the cerebral arteries, more rarely in thrombosis. Abdominal