A61-year-oldmanpresentswith apainlessplaqueon the right sideof his scrotum; theplaque first appeared 1.5yearsagoandhasbeenslowly enlarging since. The patient reports experiencing no fevers or chills since the plaque developed. On examination the bright reddish, irregularly shaped plaquemeasures4.0 × 1.5 cmandhas erosions on the surface (Figure 1). The physical examination is otherwise unremarkable. Results of complete blood cell count and differential are normal. Quiz at jama.com Figure 1.