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JAMA
Article . 1988 . Peer-reviewed
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JAMA
Article . 1988
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Immune Serum Globulin Therapy for Polymyositis

Authors: Harry B. Burke;

Immune Serum Globulin Therapy for Polymyositis

Abstract

To the Editor. —The CASE REPORT by Roifman et al 1 regarding the use of immune serum globulin in the treatment of chronic polymyositis requires clarification. The authors describe a patient with "normal immunity," but they did not provide any information regarding what this means. We need to know what immunologic studies were performed (eg, measurement of immunoglobulin, complement, and rheumatoid factor levels and antibody titers) and the results of those studies if we are going to understand what the authors mean by normal immunity. This knowledge is important because the intravenous infusion of γ-globulin has been associated with the death of a patient with abnormal immunoglobulins. 2 If there is the slightest doubt regarding the patient's immunologic status, the prudent course is to begin with a test dose of immune globulin before proceeding to a therapeutic regimen. Finally, since spontaneous remission is possible in polymyositis, it is difficult to

Keywords

Myositis, Immunization, Passive, Humans

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    14
    popularity
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    Average
    influence
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    Top 10%
    impulse
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Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Top 10%
Average
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