To the Editor.— A variety of animal 1,2 and human 3 experiments have suggested that neural transmitters may mediate some of the symptoms of alcohol intoxication and withdrawal. Also, there is evidence to suggest that a dopamine agonist (apomorphine) reduces craving for alcohol in human alcoholics 4 and ethanol stimulation in mice. 5 This raises the possibility that chemical intervention in the production of neurotransmitters might affect drinking patterns in humans who are "normal drinkers" or the craving for alcohol in alcoholics. Thus, I wish to ask physicians if they have anecdotal or experimental evidence to support this possibility. Specifically, have physicians using levodopa therapeutically in patients with parkinsonism seen any evidence suggesting significant changes in response to alcohol or in craving for alcohol? If they will write to me, I will undertake to compile data from any such reports.