To the Editor.— The statement by Hinkes and Plotkin (223:1490, 1973) that "perhaps 0.1% to 1% of patients with acute leukemia survive five or more years" gives an erroneously bleak outlook. No longer is the fiveyear survivor a rarity. Recently, Ingelfinger quoted the Director of the National Cancer Institute who said that "50 per cent of children with acute lymphocytic leukemia (who get) optimal treatment survive at least five years today. Tragically, only 15 per cent of the children afflicted get optimal treatment." 1 In an editorial reply, the Chairman of the Acute Leukemia Group B (ALGB) indicated that the ALGB data support the contention that "50 per cent of children now under optimal treatment as it is known today should survive for at least five years." 2 The directions in abbreviated form for such optimal treatment were then appended. 2 The experience of ALGB is not unique. Other cancer cooperative