I shall not attempt to review the many-sided subject of metabolism in typhoid fever, but shall devote the time to a brief discussion of one phase of the subject, which is of great importance, as well as of interest, both to the clinician and to the pathologic physiologist. During the course of the disease a typhoid patient loses from ten to sixty pounds, or even more, of his body tissue. This loss is divided among water, subcutaneous fat and protein from the body fluids or cells. The loss of water we may leave out of consideration because we know neither its amount or significance. Since the observation of Leyden1in 1869 it has been believed that there is a retention rather than a loss of water from the body in fever. This belief is supported by the decreased quantity of urine and by the supposed decrease in the evaporation