In the light of the newer pathology of diseases of the genito-urinary apparatus, involving, as it does, mainly infection of the urinary way, the neuropathic element in vesical disease is quite likely to be forgotten. It is, however, a very important point for consideration, because of, 1, the relative importance of pain,per se, in diseases of the bladder; 2, the fact that in very many instances no lesions are discoverable which explain the pain; or, at least, such lesions as are found appear too trivial to explain the severity of the pain which the patient experiences; 3, the tendency to too radical treatment in the endeavor to relieve pain by compelling a cure of lesions which are so slight that topical applications are likely to do harm rather than good. Picard1has divided cystalgia into the following classes: Cystalgia, with lesions of the urinary apparatus, i. e., lesions