The cases of cirrhosis of the liver with pigmentation of the skin or tissues, or of both together, constitute a small but most interesting group. There has been a great deal of speculation as to the etiology of these cases. The purpose of this paper is to present as briefly as possible the history of this form of cirrhosis, the clinical symptoms and pathology of the disease and the present views entertained concerning its etiology. HISTORY. Pigmentation of the skin and tissues, other than that resulting from the staining with the bile, does not occur in association with the atrophic cirrhosis of Laennec. In 49 cases of this type of cirrhosis that have been treated in the medical wards of the Johns Hopkins Hospital up to the present date, no single instance of permanent pigmentation has been observed. Of 8 cases of hypertrophic cirrhosis of the liver 1 presented a