I had the good fortune recently to see one of the rare cases of "skin-shedders." This was a man of 50, strong, hearty, quite intelligent and entertaining in his description of his peculiar condition. Family History. —He comes of a long-lived race, two of his grandparents having reached over 100 and his father being alive at about 90. He has six living brothers and sisters. No one of his family has ever been known to shed his skin. Personal History. —His parents told him that he was born in May, 1849, and that he shed all his skin in the July following, and every year of his childhood. Since he has reached years of ability to remember, he states that he has shed all the skin of his body every summer and, in the years 1893, 1894, 1899 and1900, has shed it the second time about a month later than