Approximately one third of all neuroblastomas are diagnosed in the first year of life. In most of the cases the diagnosis is made when the neoplasm is widely metastatic. It is our purpose in this report to call attention to Horner syndrome and respiratory distress as the presenting symptoms of neuroblastoma in a newborn. Report of a Case.—A girl was born at term to a 16-year-old gravida 2, para 1 mother after a normal pregnancy and delivery. Her birth weight was 3.31 kg. Physical examination at birth showed no abnormalities except mild ptosis of the left eyelid. The next day the baby had mild respiratory distress that disappeared after several hours. During the following nine days the respiratory distress became worse and stridor with cough appeared. Physical examination disclosed moderate substernal retractions and ptosis of the left eyelid. The neck was normal. The liver extended 2 cm below the