AN UNDERSTANDING of the cellular events that occur in the nose during the course of virus infections may be of importance if we are to make progress in developing satisfactory measures of preventing or treating common colds and related problems. One of the deficiencies in our knowledge in the past has been insufficient information about the location and type of cells in which virus replication occurs. The purpose of this study was to develop a satisfactory means for obtaining specimens atraumatically from the nose that would permit cytological, immunological, and virological studies, so that the sequence of events in virus infections of the human nose could be determined. Materials and Methods Subjects. —Volunteers were healthy adult men, aged 21 to 40 years, recruited from the Texas State Department of Corrections. Method of Biopsy. —Neither anesthetic agents nor vasoconstrictors were applied topically or administered systematically so that there would be no