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Microrips of the Retinal Pigment Epithelium

Authors: Mark S. Blumenkranz; Lawrence A. Yannuzzi; Darmakusuma Ie; Richard F. Spaide; Lawrence J. Singerman; Kimball P. Woodward;

Microrips of the Retinal Pigment Epithelium

Abstract

We describe six patients with exudative age-related macular degeneration who had retinal pigment epithelial detachments with associated overlying neurosensory detachments. During fluorescein angiography, each patient demonstrated a solitary, intense, central serouslike leak at the edge of the retinal pigment epithelial detachment with passage of fluorescein into the subretinal space. In patients in whom the location of associated choroidal neovascularization was evident, the leakage site was remote to the area of neovascularization. Our observations suggest that these leaks result from small retinal epithelial rips, which we termed "microrips," that differ from conventionally described retinal pigment epithelial rips in clinical course and response to laser treatment. We hypothesize that the mechanisms and forces that generate these microrips are different from those producing conventionally described retinal pigment epithelial rips.

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Keywords

Aged, 80 and over, Male, Laser Coagulation, Neovascularization, Pathologic, Choroid, Fundus Oculi, Retinal Detachment, Visual Acuity, Middle Aged, Humans, Female, Fluorescein Angiography, Pigment Epithelium of Eye, Aged

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    24
    popularity
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    Top 10%
    influence
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    Top 10%
    impulse
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Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
24
Top 10%
Top 10%
Average
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