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Single Photon Emission Computed Tomography in Alzheimer's Disease

Authors: A. Hijdra; E. A. Van Royen; J. B. K. Lanser; Joost Haan; Mayke M. A. Derix; Henry C. Weinstein; M. J. P. G. van Kroonenburgh; +1 Authors

Single Photon Emission Computed Tomography in Alzheimer's Disease

Abstract

To the Editor. —We would like to comment on the article by Johnson et al 1 that appeared in the April 1988 issue of theArchives. 1 The authors reported that single photon emission computed tomography (SPECT) brain imaging with iofetamine hydrochloride I 123 was able to reflect dementia severity in patients with Alzheimer's disease (AD). To determine dementia severity, they used a global estimate of functional disability on a 4-point scale. Dividing a group of patients with AD into several groups based on functional impairment seems rather artificial. The great range of overlap in score on the Blessed Dementia Scale 2 between the four groups (Table 1 in the article) seems to support this. In our opinion, a comparison of the whole spectrum of dementia should be made with SPECT abnormalities. Further-more, dementia severity was determined by estimating functional disability, without referring to previous ability. We think that the

Keywords

Tomography, Emission-Computed, Single-Photon, Alzheimer Disease, Brain, Humans

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Average
Top 10%
Top 10%
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