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Pancytopenia and Hepatosplenomegaly in Oxalosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1984 English Publisher:American Medical Association (AMA)Journal:Archives of Internal Medicine, volume 144, page 167 (issn: 0003-9926,

Authors: Donald E. Hricik; Rafiq Hussain;

doi: 10.1001/archinte.1984.00350130195034

pmid: 6691753

Pancytopenia and Hepatosplenomegaly in Oxalosis

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Abstract

A 25-year-old woman with oxalosis and end-stage renal disease had pancytopenia and massive hepatosplenomegaly associated with extensive bone marrow deposition of calcium oxalate. A ferrokinetic study suggested profound reduction in erythrocyte production, and peripheral blood smears were compatible with myelophthisis and extramedullary hematopoiesis. Mechanical obliteration of bone marrow by calcium oxalate crystals may lead to pancytopenia and hepatosplenomegaly as late extrarenal complications of oxalosis.

Related Organizations

Case Western Reserve University
United States

Keywords

Adult, Calcium Oxalate, Pancytopenia, Ferric Compounds, Chlorides, Bone Marrow, Splenomegaly, Humans, Kidney Failure, Chronic, Female, Hepatomegaly

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average