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The Treatment of Bullous Pemphigoid With Tetracycline and Niacinamide

A Preliminary Report

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1986Publisher:American Medical Association (AMA)Journal:Archives of Dermatology, volume 122, page 670 (issn: 0003-987X,

Authors: Mark Allan Berk; Allan L. Lorincz;

doi: 10.1001/archderm.1986.01660180076019

pmid: 2940979

The Treatment of Bullous Pemphigoid With Tetracycline and Niacinamide

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Abstract

Patients with moderate to severe bullous pemphigoid are usually treated with systemic corticosteroids. Four patients were treated with tetracycline hydrochloride and niacinamide because of the steroid-sparing anti-inflammatory properties of these agents. An excellent clinical response free of side effects was observed in all patients. The lesions recurred whenever treatment was discontinued. It is believed that these drugs suppress the complement-mediated inflammatory response at the basement membrane zone by suppressing neutrophil chemotaxis and mediators of the inflammatory response in this bullous disease.

Keywords

Male, Niacinamide, Skin Diseases, Vesiculobullous, Administration, Oral, Tetracycline, Erythromycin, Pemphigoid, Bullous, Humans, Drug Therapy, Combination, Female, Aged, Skin

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	177
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%