In general, successful treatment of any disease is probably inversely related to the number of recommended regimens. Multiple treatment methods have been proposed for granuloma annulare, a disorder that is often difficult to eliminate. We report herein our success in treating granuloma annulare with a method described by Shakhnes.1 Report of Cases Case 1.— A 59-year-old woman had multiple lesions of granuloma annulare. These had begun to appear eight years previously on the dorsum of her left foot, after which new lesions began to appear elsewhere. The patient had been previously treated by several physicians with oral vitamin E, grenz-ray irradiation, and intramuscular (IM) triamcinolone acetonide. She denied any improvement in her condition while she was receiving therapy previously. On examination, multiple annular lesions composed of firm, white to pink nodules were seen on the extensor surfaces of both arms, the upper part of the chest, and the pretibial